Purdue dissertation binding

Peripheral substituents on cationic porphyrins play a significant role during binding with DNA hosts. Possible applications of these systems in photodynamic therapy as well as in anti-bacterial and anti-cancer therapies motivate the binding studies. For characterizing DNA binding motifs different methods are useful including absorption, emission, and circular dichroism spectroscopies, as well Author: Srijana Ghimire. Non-Purdue users, may purchase copies of theses and dissertations from ProQuest or talk to your librarian about borrowing a copy through Interlibrary Loan. (Some titles may also be available free of charge in our Open Access Theses and Dissertations Series, so please check there first.). The cellular environment presents a protein with many small molecules with which it may interact. Many novel interactions between proteins and non-substrate metabolites are being uncovered through proteome-wide screens. The homodimeric Escherichia coli cofactor-dependant phosphoglycerate mutase (dPGM) was identified as an ATP binding protein in a proteome-wide screen, but dPGM does not use Author: Nathan W. Gardner. ATP-binding cassette transporters comprise a large superfamily of proteins that are involved in a variety of biological phenomenon, from bacterial metabolism to cellular homeostasis, antigen-presentation, and drug resistance. These proteins are implicated in a variety of clinically relevant phenomenon, including the human diseases cystic fibrosis, macular degeneration, and studyuniversity.info: Satchal K. Erramilli. Mar 02,  · The Purdue University Libraries collects, preserves, and provides access to dissertations as original works of scholarship in conjunction with doctorates awarded by the University. Other pertinent student works such as master's and honors theses may also be studyuniversity.info: J.P. Herubel.
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Synthesis and DNA-binding studies with two stericallyfriendly porphyrin frameworks. Srijana GhimirePurdue University. Peripheral substituents on cationic porphyrins play a significant role during binding with DNA hosts. Possible applications of these systems in photodynamic therapy as well as in anti-bacterial and anti-cancer therapies motivate the binding studies. For characterizing DNA binding motifs different dissertagion are useful including absorption, emission, purdue dissertation binding circular dichroism click to see more, as well as viscometry and X-ray crystallography.

With the classic H 2 T 4 porphyrin, purdue dissertation binding 5,10,15,tetra N-methylpyridiniumyl porphyrin, the mode of binding varies with the base composition of the DNA host.

The porphyrin binds adenine-thymine rich sequences externally whereas intercalation occurs in guanine-cytosine rich sequences. The McMillin group has made some dicationic porphyrins which are strictly intercalators but the lower positive charge decreases binding affinity to DNA. One chapter astronauts essay competitive binding studies involving a dicatonic porphyrin. Most vissertation the thesis focuses on a new system described purdue dissertation binding pkrdue is H 2 TC 3or 5,10,15,tetra[3- 3'-methylimidazolium-1'-yl ]porphyrin.

Read article comparison with the classical H 2 T 4 system, H 2 TC 3 happens. environmental imbalance essay rather a higher molar extinction coefficient but is more prone purdue dissertation binding self-association.

Findings of note include that the copper II -containing form Cu TC3 is adept at internalizing into disseration as well as B-form Purdue dissertation binding, regardless of the base composition.

Surprisingly, however, external binding of H 2 TC 3 bniding within domains that are rich in adenine-thymine base pairs. The difference in the deformability of H 2 TC 3 vs. Cu TC3 probably accounts for the reactivity difference.

On the other hand, Zn Difference argumentative essay binds externally, as the metal center purdue dissertation binding five coordinate.

Finally, the thesis describes the palladium analogue Pd TC3. It will be of interest because of the high yield of intersystem crossing and long lifetime of the resulting excited triplet state. Ghimire, Srijana, "Synthesis and DNA-binding studies with two stericallyfriendly porphyrin frameworks" purdhe Access Dissertations.

Biochemistry CommonsInorganic Chemistry Commons. Advanced Search. Privacy Copyright. Skip to main content Purdue e-Pubs. Purdue dissertation binding Synthesis and DNA-binding studies with two stericallyfriendly porphyrin frameworks. Author Srijana GhimirePurdue Ibnding. Abstract Peripheral substituents on cationic porphyrins play a significant role during binding with DNA hosts. Search Enter search terms:. Digital Commons.

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